Assay Detail
Binding
CHEMBL3790306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RET (unknown origin) in presence of [gamma33P]ATP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase receptor Ret (CHEMBL2041) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.84 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787112 | — | — | 1 | 8.10 |
| CHEMBL1614712 | — | — | 1 | 5.48 |
| CHEMBL3787614 | — | — | 1 | 5.36 |
| CHEMBL3785951 | — | — | 1 | 5.22 |
| CHEMBL3786167 | — | — | 1 | 5.03 |
| CHEMBL3785500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787112 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1614712 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3787614 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3785951 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3786167 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3785500 | — | IC50 | > | 10000.0 | nM | - |