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Assay Detail

CHEMBL3795218

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PDE4D2 catalytic domain (86 to 413 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counting method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4.
Cai YH, Guo Y, Li Z, Wu D, Li X, Zhang H, Yang J, Lu H, Sun Z, Luo HB, Yin S, Wu Y.
Eur J Med Chem (2016) 114 : 134 -140
PubMed 26978121 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.78 6.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3793675 1 6.61
CHEMBL3793522 1 6.27
CHEMBL325795 S-ROLIPRAM 1 5.97
CHEMBL3792576 1 5.18
CHEMBL3792892 1 4.88
CHEMBL3792568 1 -
CHEMBL3793371 1 -
CHEMBL3793885 1 -
CHEMBL3792407 1 -
CHEMBL3793756 1 -
CHEMBL583884 LYONISIDE 1 -
CHEMBL3793366 1 -
CHEMBL3794130 1 -
CHEMBL3342057 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3793675 IC50 = 245.0 nM 6.61
CHEMBL3793522 IC50 = 542.0 nM 6.27
CHEMBL325795 S-ROLIPRAM IC50 = 1062.0 nM 5.97
CHEMBL3792576 IC50 = 6568.0 nM 5.18
CHEMBL3792892 IC50 = 13273.0 nM 4.88
CHEMBL3792568 IC50 > 20000.0 nM -
CHEMBL3793371 IC50 > 20000.0 nM -
CHEMBL3793885 IC50 > 20000.0 nM -
CHEMBL3792407 IC50 > 20000.0 nM -
CHEMBL3793756 IC50 > 20000.0 nM -
CHEMBL583884 LYONISIDE IC50 > 20000.0 nM -
CHEMBL3793366 IC50 > 20000.0 nM -
CHEMBL3794130 IC50 > 20000.0 nM -
CHEMBL3342057 IC50 > 20000.0 nM -