Assay Detail
Binding
CHEMBL3795243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig gastric H+/K+-ATPase in stomach ion leaky membrane vesicle assessed as reduction in monophosphate production after 30 mins by microplate reader analysis in presence of valinomycin
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Stomach |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of bisabolangelone oxime derivatives as potassium-competitive acid blockers (P-CABs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.94 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793140 | — | — | 1 | 6.36 |
| CHEMBL3792909 | — | — | 1 | 6.25 |
| CHEMBL3792908 | — | — | 1 | 6.07 |
| CHEMBL1618279 | REVAPRAZAN | 2.0 | 1 | 6.02 |
| CHEMBL3793211 | — | — | 1 | 6.00 |
| CHEMBL3793451 | — | — | 1 | 5.94 |
| CHEMBL3792708 | — | — | 1 | 5.54 |
| CHEMBL3793888 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793140 | — | IC50 | = | 436.52 | nM | 6.36 |
| CHEMBL3792909 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL3792908 | — | IC50 | = | 851.14 | nM | 6.07 |
| CHEMBL1618279 | REVAPRAZAN | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3793211 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3793451 | — | IC50 | = | 1148.15 | nM | 5.94 |
| CHEMBL3792708 | — | IC50 | = | 2884.03 | nM | 5.54 |
| CHEMBL3793888 | — | IC50 | = | 5011.87 | nM | 5.30 |