Assay Detail
Binding
CHEMBL3795379
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Binding affinity to Bcl-2 (unknown origin) by FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.68 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793424 | — | — | 1 | 8.22 |
| CHEMBL3342332 | A-1155463 | — | 1 | 7.13 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | - |
| CHEMBL3794549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793424 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3342332 | A-1155463 | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL3137309 | VENETOCLAX | Ki | < | 0.01 | nM | - |
| CHEMBL3794549 | — | Ki | < | 0.1 | nM | - |