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Assay Detail

CHEMBL3795663

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine tubulin polymerization after 1 hr by fluorescence spectrometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Tubulin (CHEMBL2094134)
Type PROTEIN FAMILY
Organism Bos taurus

Publication

Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents.
Driowya M, Leclercq J, Verones V, Barczyk A, Lecoeur M, Renault N, Flouquet N, Ghinet A, Berthelot P, Lebegue N.
Eur J Med Chem (2016) 115 : 393 -405
PubMed 27031215 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.10 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3793652 1 6.82
CHEMBL3794202 1 5.37
CHEMBL3794460 1 -
CHEMBL3793564 1 -
CHEMBL3792547 1 -
CHEMBL3793547 1 -
CHEMBL3792513 1 -
CHEMBL3793323 1 -
CHEMBL3793124 1 -
CHEMBL3793967 1 -
CHEMBL3792479 1 -
CHEMBL3794178 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3793652 IC50 = 150.0 nM 6.82
CHEMBL3794202 IC50 = 4260.0 nM 5.37
CHEMBL3794460 IC50 > 10000.0 nM -
CHEMBL3793564 IC50 > 10000.0 nM -
CHEMBL3792547 IC50 > 10000.0 nM -
CHEMBL3793547 IC50 > 10000.0 nM -
CHEMBL3792513 IC50 > 10000.0 nM -
CHEMBL3793323 IC50 > 10000.0 nM -
CHEMBL3793124 IC50 > 10000.0 nM -
CHEMBL3793967 IC50 > 10000.0 nM -
CHEMBL3792479 IC50 > 10000.0 nM -
CHEMBL3794178 IC50 > 10000.0 nM -