Assay Detail
Functional
CHEMBL3795969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by celltiter Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Strategies for improving the solubility and metabolic stability of griseofulvin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.25 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522298 | — | — | 1 | 5.89 |
| CHEMBL521969 | — | — | 1 | 5.79 |
| CHEMBL3792939 | — | — | 1 | 5.27 |
| CHEMBL3794498 | — | — | 1 | 5.00 |
| CHEMBL3794566 | — | — | 1 | 4.93 |
| CHEMBL562 | GRISEOFULVIN | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522298 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL521969 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL3792939 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL3794498 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3794566 | — | IC50 | = | 11770.0 | nM | 4.93 |
| CHEMBL562 | GRISEOFULVIN | IC50 | = | 25330.0 | nM | 4.60 |