Assay Detail
Functional
CHEMBL3795970
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability after 72 hrs by celltiter Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Strategies for improving the solubility and metabolic stability of griseofulvin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.20 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521969 | — | — | 1 | 5.84 |
| CHEMBL522298 | — | — | 1 | 5.79 |
| CHEMBL3792939 | — | — | 1 | 5.25 |
| CHEMBL3794498 | — | — | 1 | 4.85 |
| CHEMBL3794566 | — | — | 1 | 4.84 |
| CHEMBL562 | GRISEOFULVIN | 4.0 | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521969 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL522298 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3792939 | — | IC50 | = | 5560.0 | nM | 5.25 |
| CHEMBL3794498 | — | IC50 | = | 14130.0 | nM | 4.85 |
| CHEMBL3794566 | — | IC50 | = | 14320.0 | nM | 4.84 |
| CHEMBL562 | GRISEOFULVIN | IC50 | = | 22440.0 | nM | 4.65 |