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Assay Detail

CHEMBL3796107

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Functional
Antiviral activity against HCV infected in HuH7 Clone B cells assessed as inhibition of viral replication after 5 days by RT-PCR method
ChEMBL ↗
72
Total Activities
36
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type B
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.
Zhou L, Zhang H, Tao S, Ehteshami M, Cho JH, McBrayer TR, Tharnish P, Whitaker T, Amblard F, Coats SJ, Schinazi RF.
ACS Med Chem Lett (2016) 7 : 17 -22
PubMed 26819659 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 36 5.94 7.70
EC90 36 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1209734 BMS-986094 2.0 2 7.70
CHEMBL3793980 — — 2 6.52
CHEMBL3793161 — — 2 6.52
CHEMBL3793223 — — 2 6.52
CHEMBL3793206 — — 2 6.05
CHEMBL3794586 — — 2 6.00
CHEMBL3793015 — — 2 5.77
CHEMBL3793481 — — 2 5.72
CHEMBL3793475 — — 2 5.64
CHEMBL3793947 — — 2 5.62
CHEMBL3792961 — — 2 5.62
CHEMBL3792901 — — 2 5.57
CHEMBL3794521 — — 2 5.39
CHEMBL3794324 — — 2 5.32
CHEMBL3792887 — — 2 5.20
CHEMBL3794425 — — 2 -
CHEMBL3794047 — — 2 -
CHEMBL3794266 — — 2 -
CHEMBL3793038 — — 2 -
CHEMBL3793714 — — 2 -
CHEMBL3793064 — — 2 -
CHEMBL3794122 — — 2 -
CHEMBL3792530 — — 2 -
CHEMBL1911741 — — 2 -
CHEMBL3793806 — — 2 -
CHEMBL3793909 — — 2 -
CHEMBL3793507 — — 2 -
CHEMBL3794107 — — 2 -
CHEMBL3793828 — — 2 -
CHEMBL3792817 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1209734 BMS-986094 EC50 = 20.0 nM 7.70
CHEMBL3793980 — EC50 = 300.0 nM 6.52
CHEMBL3793161 — EC50 = 300.0 nM 6.52
CHEMBL3793223 — EC50 = 300.0 nM 6.52
CHEMBL3793206 — EC50 = 900.0 nM 6.05
CHEMBL3794586 — EC50 = 1000.0 nM 6.00
CHEMBL3793015 — EC50 = 1700.0 nM 5.77
CHEMBL3793481 — EC50 = 1900.0 nM 5.72
CHEMBL3793475 — EC50 = 2300.0 nM 5.64
CHEMBL3792961 — EC50 = 2400.0 nM 5.62
CHEMBL3793947 — EC50 = 2400.0 nM 5.62
CHEMBL3792901 — EC50 = 2700.0 nM 5.57
CHEMBL3794521 — EC50 = 4100.0 nM 5.39
CHEMBL3794324 — EC50 = 4800.0 nM 5.32
CHEMBL3792887 — EC50 = 6300.0 nM 5.20
CHEMBL3794521 — EC90 = 9.2 uM -
CHEMBL3792538 — EC50 > 10000.0 nM -
CHEMBL3794122 — EC90 > 10.0 uM -
CHEMBL3792530 — EC90 > 10.0 uM -
CHEMBL1911741 — EC90 > 10.0 uM -
CHEMBL3793475 — EC90 = 3.0 uM -
CHEMBL3793806 — EC90 > 10.0 uM -
CHEMBL3792901 — EC90 = 8.3 uM -
CHEMBL3793909 — EC90 > 10.0 uM -
CHEMBL3793507 — EC90 > 10.0 uM -
CHEMBL3793161 — EC90 = 0.9 uM -
CHEMBL3793828 — EC50 > 10000.0 nM -
CHEMBL3793064 — EC50 > 10000.0 nM -
CHEMBL3794107 — EC50 > 10000.0 nM -
CHEMBL3793038 — EC50 > 10000.0 nM -
CHEMBL3793952 — EC50 > 10000.0 nM -
CHEMBL1911734 — EC50 > 10000.0 nM -
CHEMBL1911738 — EC90 > 10.0 uM -
CHEMBL3794425 — EC90 > 10.0 uM -
CHEMBL3793599 — EC90 > 10.0 uM -
CHEMBL3794047 — EC90 > 10.0 uM -
CHEMBL3793038 — EC90 > 10.0 uM -
CHEMBL3794324 — EC90 = 10.0 uM -
CHEMBL3792887 — EC90 = 9.9 uM -
CHEMBL1911739 — EC90 > 10.0 uM -
CHEMBL3793015 — EC90 = 5.3 uM -
CHEMBL3793064 — EC90 > 10.0 uM -
CHEMBL3792538 — EC90 > 10.0 uM -
CHEMBL1911734 — EC90 > 10.0 uM -
CHEMBL3793952 — EC90 > 10.0 uM -
CHEMBL1209734 BMS-986094 EC90 = 0.04 uM -
CHEMBL3794266 — EC90 > 10.0 uM -
CHEMBL3794586 — EC90 = 2.8 uM -
CHEMBL3792817 — EC90 > 10.0 uM -
CHEMBL3793714 — EC90 > 10.0 uM -