Assay Detail
Binding
CHEMBL3796259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Oxidized purine nucleoside triphosphate hydrolase (CHEMBL3708265) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
MutT Homolog 1 (MTH1): The Silencing of a Target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.77 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3792684 | — | — | 1 | 9.30 |
| CHEMBL3794167 | — | — | 1 | 9.30 |
| CHEMBL3781316 | — | — | 1 | 9.05 |
| CHEMBL3782004 | — | — | 1 | 8.15 |
| CHEMBL3794132 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3792684 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3794167 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3781316 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3782004 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3794132 | — | IC50 | = | 9.0 | nM | 8.05 |