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Assay Detail

CHEMBL3796289

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human CK2 holoenzyme using RRRADDSDDDDD as substrate measured after 10 mins at 37 degC by radiometric kinase assay in presence of [gamma-32P]ATP
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Casein kinase II (CHEMBL2095191)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

Design and synthesis of novel protein kinase CK2 inhibitors on the base of 4-aminothieno[2,3-d]pyrimidines.
Ostrynska OV, Balanda AO, Bdzhola VG, Golub AG, Kotey IM, Kukharenko OP, Gryshchenko AA, Briukhovetska NV, Yarmoluk SM.
Eur J Med Chem (2016) 115 : 148 -160
PubMed 27017545 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.22 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29898 QUINALIZARIN 1 7.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29898 QUINALIZARIN Ki = 60.0 nM 7.22