Assay Detail
Functional
CHEMBL3796495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Disruption of trabecular meshwork in human TM1 cells assessed as actin fiber length and focal adhesions by Hoechst staining based analysis
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TM1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 6.65 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793381 | — | — | 1 | 7.85 |
| CHEMBL3794308 | — | — | 1 | 7.42 |
| CHEMBL3792673 | — | — | 1 | 7.41 |
| CHEMBL3793688 | — | — | 1 | 7.36 |
| CHEMBL3793004 | — | — | 1 | 7.33 |
| CHEMBL3793538 | — | — | 1 | 7.33 |
| CHEMBL3792888 | — | — | 1 | 7.32 |
| CHEMBL3793788 | — | — | 1 | 7.19 |
| CHEMBL3794104 | — | — | 1 | 7.19 |
| CHEMBL3792412 | — | — | 1 | 7.19 |
| CHEMBL3793969 | — | — | 1 | 7.16 |
| CHEMBL3792969 | — | — | 1 | 7.14 |
| CHEMBL3792599 | — | — | 1 | 7.13 |
| CHEMBL3794444 | — | — | 1 | 7.08 |
| CHEMBL3793489 | — | — | 1 | 7.05 |
| CHEMBL3792921 | — | — | 1 | 6.99 |
| CHEMBL3793516 | — | — | 1 | 6.96 |
| CHEMBL3793029 | — | — | 1 | 6.93 |
| CHEMBL3770836 | — | — | 1 | 6.91 |
| CHEMBL3794270 | — | — | 1 | 6.86 |
| CHEMBL3792435 | — | — | 1 | 6.81 |
| CHEMBL3794435 | — | — | 1 | 6.78 |
| CHEMBL3792549 | — | — | 1 | 6.72 |
| CHEMBL3793497 | — | — | 1 | 6.71 |
| CHEMBL3792663 | — | — | 1 | 6.71 |
| CHEMBL3792666 | — | — | 1 | 6.70 |
| CHEMBL3793404 | — | — | 1 | 6.68 |
| CHEMBL3793153 | — | — | 1 | 6.67 |
| CHEMBL3792593 | — | — | 1 | 6.67 |
| CHEMBL3792581 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793381 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3794308 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3792673 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3793688 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3793004 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3793538 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3792888 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3793788 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3794104 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3792412 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3793969 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3792969 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3792599 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3794444 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3793489 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3792921 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3793516 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL3793029 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL3770836 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL3794270 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL3792435 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL3794435 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL3792549 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3793497 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL3792663 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL3792666 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL3793404 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL3793153 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL3792593 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL3792581 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL3792689 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL3794389 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3792781 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL3794409 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL3793203 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL3794198 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL3793659 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3793505 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL3793243 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL3793235 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL3794298 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL3792612 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL3793245 | — | IC50 | = | 1216.0 | nM | 5.92 |
| CHEMBL3793870 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL3792734 | — | IC50 | = | 1721.0 | nM | 5.76 |
| CHEMBL3792603 | — | IC50 | = | 2459.0 | nM | 5.61 |
| CHEMBL3793296 | — | IC50 | = | 4239.0 | nM | 5.37 |
| CHEMBL3793368 | — | IC50 | = | 4239.0 | nM | 5.37 |
| CHEMBL3770730 | — | IC50 | = | 5609.0 | nM | 5.25 |
| CHEMBL3794254 | — | IC50 | = | 11002.0 | nM | 4.96 |