Assay Detail
Binding
CHEMBL3800919
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine pancreatic lipase using p-nitrophenyl butyrate as substrate assessed as formation of p-nitrophenol preincubated for 10 mins followed by substrate addition by spectrophotometric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.45 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | 4.0 | 1 | 7.92 |
| CHEMBL517247 | MULBERROFURAN D | — | 1 | 7.05 |
| CHEMBL3800462 | — | — | 1 | 6.41 |
| CHEMBL3797266 | — | — | 1 | 6.32 |
| CHEMBL3800628 | — | — | 1 | 6.24 |
| CHEMBL562810 | MULBERROFURAN W | — | 1 | 6.16 |
| CHEMBL3798170 | — | — | 1 | 6.15 |
| CHEMBL3800241 | — | — | 1 | 6.12 |
| CHEMBL3798236 | — | — | 1 | 6.07 |
| CHEMBL3797932 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL517247 | MULBERROFURAN D | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3800462 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3797266 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3800628 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL562810 | MULBERROFURAN W | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3798170 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3800241 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3798236 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3797932 | — | IC50 | = | 920.0 | nM | 6.04 |