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Assay Detail

CHEMBL3801002

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Binding
Binding affinity to human recombinant CA2 expressed in Escherichia coli after 30 secs by surface plasmon resonance assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII.
Talibov VO, Linkuvienė V, Matulis D, Danielson UH.
J Med Chem (2016) 59 : 2083 -2093
PubMed 26805033 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 15 7.26 8.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2011156 1 8.28
CHEMBL3798446 1 8.22
CHEMBL3799577 1 8.19
CHEMBL3797893 1 8.17
CHEMBL2443188 1 7.96
CHEMBL2010994 1 7.33
CHEMBL3799945 1 7.18
CHEMBL3798303 1 7.00
CHEMBL2011155 1 6.89
CHEMBL1272242 1 6.48
CHEMBL1272187 1 6.28
CHEMBL2443189 1 6.28
CHEMBL3799296 1 6.12
CHEMBL3797385 1 -
CHEMBL3797835 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2011156 Kd = 5.2 nM 8.28
CHEMBL3798446 Kd = 6.0 nM 8.22
CHEMBL3799577 Kd = 6.4 nM 8.19
CHEMBL3797893 Kd = 6.8 nM 8.17
CHEMBL2443188 Kd = 11.0 nM 7.96
CHEMBL2010994 Kd = 47.0 nM 7.33
CHEMBL3799945 Kd = 66.0 nM 7.18
CHEMBL3798303 Kd = 100.0 nM 7.00
CHEMBL2011155 Kd = 130.0 nM 6.89
CHEMBL1272242 Kd = 330.0 nM 6.48
CHEMBL1272187 Kd = 530.0 nM 6.28
CHEMBL2443189 Kd = 520.0 nM 6.28
CHEMBL3799296 Kd = 760.0 nM 6.12
CHEMBL3797385 Kd - -
CHEMBL3797835 Kd - -