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Assay Detail

CHEMBL3801003

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human recombinant CA2 expressed in Escherichia coli by fluorescence-based thermal shift assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII.
Talibov VO, Linkuvienė V, Matulis D, Danielson UH.
J Med Chem (2016) 59 : 2083 -2093
PubMed 26805033 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 17 7.62 9.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3798473 1 9.23
CHEMBL2333418 1 9.04
CHEMBL3797385 1 8.82
CHEMBL3799577 1 8.62
CHEMBL3798446 1 8.48
CHEMBL2443188 1 8.48
CHEMBL3797893 1 8.35
CHEMBL2011156 1 8.15
CHEMBL2010994 1 7.77
CHEMBL3798303 1 7.70
CHEMBL3799945 1 7.11
CHEMBL2011155 1 6.85
CHEMBL2443189 1 6.37
CHEMBL3797835 1 6.35
CHEMBL1272187 1 6.23
CHEMBL1272242 1 6.17
CHEMBL3799296 1 5.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3798473 Kd = 0.59 nM 9.23
CHEMBL2333418 Kd = 0.91 nM 9.04
CHEMBL3797385 Kd = 1.5 nM 8.82
CHEMBL3799577 Kd = 2.4 nM 8.62
CHEMBL3798446 Kd = 3.3 nM 8.48
CHEMBL2443188 Kd = 3.3 nM 8.48
CHEMBL3797893 Kd = 4.5 nM 8.35
CHEMBL2011156 Kd = 7.1 nM 8.15
CHEMBL2010994 Kd = 17.0 nM 7.77
CHEMBL3798303 Kd = 20.0 nM 7.70
CHEMBL3799945 Kd = 77.0 nM 7.11
CHEMBL2011155 Kd = 140.0 nM 6.85
CHEMBL2443189 Kd = 430.0 nM 6.37
CHEMBL3797835 Kd = 450.0 nM 6.35
CHEMBL1272187 Kd = 590.0 nM 6.23
CHEMBL1272242 Kd = 670.0 nM 6.17
CHEMBL3799296 Kd = 1700.0 nM 5.77