Assay Detail
Binding
CHEMBL3801112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP/10 uM ATP addition measured after 120 mins by radiometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydro-pyrimido-indoles as selective LIMK inhibitors: synthesis, selectivity profiling and structureactivity studies
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356433 | LX-7101 | 1.0 | 1 | 8.00 |
| CHEMBL3799326 | — | — | 1 | - |
| CHEMBL3797874 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356433 | LX-7101 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3799326 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3797874 | — | IC50 | > | 1000.0 | nM | - |