Assay Detail
Binding
CHEMBL3801197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FAM-Bid peptide from N-terminal 8x His-tagged MCl-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) after 30 mins by fluorescence polarization assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bcl-2/MDM2 Dual Inhibitors Based on Universal Pyramid-Like α-Helical Mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.18 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3798634 | — | — | 1 | 7.10 |
| CHEMBL3799491 | — | — | 1 | 7.09 |
| CHEMBL3799447 | — | — | 1 | 6.79 |
| CHEMBL3799930 | — | — | 1 | 6.65 |
| CHEMBL3798644 | — | — | 1 | 6.61 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.58 |
| CHEMBL3799627 | — | — | 1 | 6.43 |
| CHEMBL3797344 | — | — | 1 | 6.41 |
| CHEMBL3800181 | — | — | 1 | 6.39 |
| CHEMBL3798160 | — | — | 1 | 6.35 |
| CHEMBL3799456 | — | — | 1 | 6.20 |
| CHEMBL3798676 | — | — | 1 | 6.14 |
| CHEMBL3798048 | — | — | 1 | 5.62 |
| CHEMBL3797361 | — | — | 1 | 5.58 |
| CHEMBL3799056 | — | — | 1 | 5.44 |
| CHEMBL3800016 | — | — | 1 | 5.42 |
| CHEMBL3798424 | — | — | 1 | 5.34 |
| CHEMBL3800356 | — | — | 1 | 5.09 |
| CHEMBL3798868 | — | — | 1 | - |
| CHEMBL1709075 | — | — | 1 | - |
| CHEMBL3798797 | — | — | 1 | - |
| CHEMBL191334 | NUTLIN-3 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3798634 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL3799491 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL3799447 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL3799930 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL3798644 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL3799627 | — | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL3797344 | — | Ki | = | 393.0 | nM | 6.41 |
| CHEMBL3800181 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL3798160 | — | Ki | = | 451.0 | nM | 6.35 |
| CHEMBL3799456 | — | Ki | = | 635.0 | nM | 6.20 |
| CHEMBL3798676 | — | Ki | = | 722.0 | nM | 6.14 |
| CHEMBL3798048 | — | Ki | = | 2390.0 | nM | 5.62 |
| CHEMBL3797361 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL3799056 | — | Ki | = | 3620.0 | nM | 5.44 |
| CHEMBL3800016 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL3798424 | — | Ki | = | 4520.0 | nM | 5.34 |
| CHEMBL3800356 | — | Ki | = | 8110.0 | nM | 5.09 |
| CHEMBL3798868 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1709075 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3798797 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL191334 | NUTLIN-3 | Ki | > | 10000.0 | nM | - |