Assay Detail
Binding
CHEMBL3801216
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Binding affinity to human recombinant CA9 catalytic domain assessed as dissociation constant calculated from kinetic parameters at pH 6 by surface plasmon resonance assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.43 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3797835 | — | — | 1 | 6.85 |
| CHEMBL2011156 | — | — | 1 | 6.48 |
| CHEMBL2010994 | — | — | 1 | 6.44 |
| CHEMBL2443188 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3797835 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL2011156 | — | Kd | = | 330.0 | nM | 6.48 |
| CHEMBL2010994 | — | Kd | = | 360.0 | nM | 6.44 |
| CHEMBL2443188 | — | Kd | = | 1100.0 | nM | 5.96 |