Assay Detail
Functional
CHEMBL3801236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR9A receptor (unknown origin) overexpressed in human MOLT4 cells assessed as inhibition of CCL25-induced increase in intracellular calcium level preincubated for 1 hr followed CCL25 addition by FLIPR assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A New Series of Orally Bioavailable Chemokine Receptor 9 (CCR9) Antagonists; Possible Agents for the Treatment of Inflammatory Bowel Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.92 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3799229 | — | — | 1 | 8.52 |
| CHEMBL2178578 | VERCIRNON | 3.0 | 1 | 8.43 |
| CHEMBL3799111 | — | — | 1 | 8.22 |
| CHEMBL3798186 | — | — | 1 | 8.22 |
| CHEMBL3798368 | — | — | 1 | 8.22 |
| CHEMBL3798178 | — | — | 1 | 8.00 |
| CHEMBL3798612 | — | — | 1 | 7.92 |
| CHEMBL3800062 | — | — | 1 | 7.92 |
| CHEMBL3797271 | — | — | 1 | 7.89 |
| CHEMBL3800135 | — | — | 1 | 7.77 |
| CHEMBL3799853 | — | — | 1 | 7.58 |
| CHEMBL3797858 | — | — | 1 | 7.57 |
| CHEMBL3799487 | — | — | 1 | 7.46 |
| CHEMBL3799220 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3799229 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2178578 | VERCIRNON | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL3799111 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3798186 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3798368 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL3798178 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3798612 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3800062 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3797271 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3800135 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL3799853 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3797858 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3799487 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL3799220 | — | Ki | = | 74.0 | nM | 7.13 |