Assay Detail
Binding
CHEMBL3801237
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Antagonist activity at CCR9 receptor in human MOLT4 cells assessed as inhibition of CCl25-mediated cell migration preincubated for 30 mins followed CCL25 addition incubated for 2 hrs by ChemoTx plate system
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A New Series of Orally Bioavailable Chemokine Receptor 9 (CCR9) Antagonists; Possible Agents for the Treatment of Inflammatory Bowel Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.54 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3799487 | — | — | 1 | 8.52 |
| CHEMBL3798612 | — | — | 1 | 8.05 |
| CHEMBL2178578 | VERCIRNON | 3.0 | 1 | 8.00 |
| CHEMBL3800062 | — | — | 1 | 7.85 |
| CHEMBL3799111 | — | — | 1 | 7.72 |
| CHEMBL3797271 | — | — | 1 | 7.62 |
| CHEMBL3799229 | — | — | 1 | 7.50 |
| CHEMBL3799220 | — | — | 1 | 7.42 |
| CHEMBL3798178 | — | — | 1 | 7.40 |
| CHEMBL3799853 | — | — | 1 | 7.04 |
| CHEMBL3798368 | — | — | 1 | 6.95 |
| CHEMBL3797858 | — | — | 1 | 6.45 |
| CHEMBL3800135 | — | — | 1 | - |
| CHEMBL3798186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3799487 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3798612 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL2178578 | VERCIRNON | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3800062 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3799111 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3797271 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3799229 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL3799220 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL3798178 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3799853 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL3798368 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL3797858 | — | Ki | = | 357.0 | nM | 6.45 |
| CHEMBL3800135 | — | Ki | > | 100.0 | nM | - |
| CHEMBL3798186 | — | Ki | > | 300.0 | nM | - |