Assay Detail
Binding
CHEMBL3801490
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Agonist activity at ARMS2-PK-tagged D2S receptor (unknown origin) transfected in HEK293 cells after 5 hrs by beta-arrestin assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.86 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 7.07 |
| CHEMBL3799455 | — | — | 1 | 6.62 |
| CHEMBL3800341 | — | — | 1 | 5.96 |
| CHEMBL3800636 | — | — | 1 | 5.58 |
| CHEMBL3797205 | — | — | 1 | 5.06 |
| CHEMBL3798748 | — | — | 1 | 4.89 |
| CHEMBL3800400 | — | — | 1 | - |
| CHEMBL3800468 | — | — | 1 | - |
| CHEMBL3799427 | — | — | 1 | - |
| CHEMBL3799593 | — | — | 1 | - |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3799455 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3800341 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3800636 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3797205 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3798748 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3800400 | — | EC50 | - | — | - | |
| CHEMBL3800468 | — | EC50 | - | — | - | |
| CHEMBL3799427 | — | EC50 | - | — | - | |
| CHEMBL3799593 | — | EC50 | - | — | - | |
| CHEMBL434 | ISOPROTERENOL | EC50 | - | — | - |