Assay Detail
Binding
CHEMBL3801666
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]7-OH-DPAT from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.37 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285755 | — | — | 1 | 8.83 |
| CHEMBL3797209 | — | — | 1 | 8.47 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.12 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.10 |
| CHEMBL3799626 | — | — | 1 | 7.90 |
| CHEMBL3800165 | — | — | 1 | 7.66 |
| CHEMBL434665 | — | — | 1 | 7.59 |
| CHEMBL26181 | — | — | 1 | 7.57 |
| CHEMBL3798179 | — | — | 1 | 7.11 |
| CHEMBL3799157 | — | — | 1 | 7.00 |
| CHEMBL3797740 | — | — | 1 | 6.98 |
| CHEMBL3798803 | — | — | 1 | 6.85 |
| CHEMBL3800633 | — | — | 1 | 6.59 |
| CHEMBL419792 | SUMANIROLE | 3.0 | 1 | 6.26 |
| CHEMBL3799271 | — | — | 1 | 5.47 |
| CHEMBL3798018 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285755 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL3797209 | — | Ki | = | 3.39 | nM | 8.47 |
| CHEMBL59 | DOPAMINE | Ki | = | 7.58 | nM | 8.12 |
| CHEMBL240773 | QUINPIROLE | Ki | = | 8.01 | nM | 8.10 |
| CHEMBL3799626 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL3800165 | — | Ki | = | 21.7 | nM | 7.66 |
| CHEMBL434665 | — | Ki | = | 25.5 | nM | 7.59 |
| CHEMBL26181 | — | Ki | = | 27.1 | nM | 7.57 |
| CHEMBL3798179 | — | Ki | = | 76.9 | nM | 7.11 |
| CHEMBL3799157 | — | Ki | = | 99.5 | nM | 7.00 |
| CHEMBL3797740 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL3798803 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL3800633 | — | Ki | = | 256.0 | nM | 6.59 |
| CHEMBL419792 | SUMANIROLE | Ki | = | 546.0 | nM | 6.26 |
| CHEMBL3799271 | — | Ki | = | 3390.0 | nM | 5.47 |
| CHEMBL3798018 | — | Ki | - | — | - |