Assay Detail
Binding
CHEMBL3801686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DTG from sigma2 receptor in rat liver homogenate incubated for 120 mins by solid scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.91 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.24 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.11 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 7.01 |
| CHEMBL3797704 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 57.5 | nM | 7.24 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 78.1 | nM | 7.11 |
| CHEMBL319706 | (S)-IFENPRODIL | Ki | = | 98.3 | nM | 7.01 |
| CHEMBL3797704 | — | Ki | = | 549.0 | nM | 6.26 |