Assay Detail

CHEMBL3801689

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to Xenopus laevis GluN2B expressed in HEK293S GnTI- cells by scintillation proximity assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Xenopus laevis
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists.

Lütnant I, Schepmann D, Wünsch B.
Eur J Med Chem (2016) 116 : 136 -146
PubMed 27061977 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.88	7.88

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL319706	(S)-IFENPRODIL	—	1	7.88

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL319706	(S)-IFENPRODIL	IC50	=	13.3	nM	7.88