Assay Detail
Binding
CHEMBL3801720
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Inhibition of TNF alpha-induced NF-kappaB (unknown origin) activation in HEK293 cells after 6 hrs by luciferase reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.58 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3798375 | — | — | 1 | 6.31 |
| CHEMBL438139 | ROCAGLAMIDE | — | 1 | 5.58 |
| CHEMBL3798054 | — | — | 1 | 5.23 |
| CHEMBL3800586 | — | — | 1 | 5.19 |
| CHEMBL459814 | AVAROL | — | 1 | - |
| CHEMBL3800631 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3798375 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL438139 | ROCAGLAMIDE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3798054 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3800586 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL459814 | AVAROL | IC50 | > | 10000.0 | nM | - |
| CHEMBL3800631 | — | IC50 | > | 10000.0 | nM | - |