Assay Detail
Functional
CHEMBL3801746
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Agonist activity at human S1P1 receptor expressed in CHO cell membranes after 45 mins by [35S]-GTPgammaS binding assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 8.87 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3799701 | — | — | 1 | 9.57 |
| CHEMBL3797951 | — | — | 1 | 9.52 |
| CHEMBL3800091 | — | — | 1 | 9.41 |
| CHEMBL3799693 | — | — | 1 | 9.36 |
| CHEMBL3800257 | — | — | 1 | 9.36 |
| CHEMBL3794064 | — | — | 1 | 9.33 |
| CHEMBL3798735 | — | — | 1 | 9.27 |
| CHEMBL3797415 | — | — | 1 | 9.25 |
| CHEMBL3800349 | — | — | 1 | 9.01 |
| CHEMBL3798784 | — | — | 1 | 9.00 |
| CHEMBL3800513 | — | — | 1 | 8.89 |
| CHEMBL3800595 | — | — | 1 | 8.80 |
| CHEMBL3799276 | — | — | 1 | 8.77 |
| CHEMBL3798775 | — | — | 1 | 8.49 |
| CHEMBL3800122 | — | — | 1 | 8.30 |
| CHEMBL3798531 | — | — | 1 | 8.28 |
| CHEMBL3798560 | — | — | 1 | 7.60 |
| CHEMBL3799501 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3799701 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL3797951 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3800091 | — | EC50 | = | 0.39 | nM | 9.41 |
| CHEMBL3799693 | — | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL3800257 | — | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL3794064 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL3798735 | — | EC50 | = | 0.54 | nM | 9.27 |
| CHEMBL3797415 | — | EC50 | = | 0.56 | nM | 9.25 |
| CHEMBL3800349 | — | EC50 | = | 0.98 | nM | 9.01 |
| CHEMBL3798784 | — | EC50 | = | 0.99 | nM | 9.00 |
| CHEMBL3800513 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3800595 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3799276 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3798775 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3800122 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3798531 | — | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3798560 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3799501 | — | EC50 | = | 44.0 | nM | 7.36 |