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Assay Detail

CHEMBL3801874

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MAO-B using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometric analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase.
Chirkova ZV, Kabanova MV, Filimonov SI, Abramov IG, Petzer A, Petzer JP, Suponitsky KY.
Bioorg Med Chem Lett (2016) 26 : 2214 -2219
PubMed 27020523 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 37 5.52 7.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL396778 SAFINAMIDE 4.0 1 7.32
CHEMBL279390 LAZABEMIDE 2.0 1 7.04
CHEMBL3799699 1 6.24
CHEMBL3800008 1 6.09
CHEMBL3798677 1 6.04
CHEMBL3799798 1 5.92
CHEMBL3797630 1 5.75
CHEMBL3800320 1 5.71
CHEMBL3800292 1 5.43
CHEMBL3797878 1 5.17
CHEMBL3799207 1 5.13
CHEMBL3797838 1 5.09
CHEMBL3798540 1 4.99
CHEMBL3797476 1 4.25
CHEMBL3799754 1 4.13
CHEMBL3798815 1 4.08
CHEMBL3798693 1 -
CHEMBL3797374 1 -
CHEMBL3799429 1 -
CHEMBL3798483 1 -
CHEMBL3797944 1 -
CHEMBL3799361 1 -
CHEMBL3799526 1 -
CHEMBL3799080 1 -
CHEMBL3798998 1 -
CHEMBL3800179 1 -
CHEMBL3799006 1 -
CHEMBL3797384 1 -
CHEMBL3799747 1 -
CHEMBL3798000 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL396778 SAFINAMIDE IC50 = 48.0 nM 7.32
CHEMBL279390 LAZABEMIDE IC50 = 91.0 nM 7.04
CHEMBL3799699 IC50 = 581.0 nM 6.24
CHEMBL3800008 IC50 = 821.0 nM 6.09
CHEMBL3798677 IC50 = 923.0 nM 6.04
CHEMBL3799798 IC50 = 1210.0 nM 5.92
CHEMBL3797630 IC50 = 1790.0 nM 5.75
CHEMBL3800320 IC50 = 1940.0 nM 5.71
CHEMBL3800292 IC50 = 3750.0 nM 5.43
CHEMBL3797878 IC50 = 6790.0 nM 5.17
CHEMBL3799207 IC50 = 7460.0 nM 5.13
CHEMBL3797838 IC50 = 8090.0 nM 5.09
CHEMBL3798540 IC50 = 10300.0 nM 4.99
CHEMBL3797476 IC50 = 56200.0 nM 4.25
CHEMBL3799754 IC50 = 74800.0 nM 4.13
CHEMBL3798815 IC50 = 83100.0 nM 4.08
CHEMBL3800329 IC50 > 100000.0 nM -
CHEMBL3797506 IC50 > 100000.0 nM -
CHEMBL3797294 IC50 > 100000.0 nM -
CHEMBL3799394 IC50 > 100000.0 nM -
CHEMBL3800487 IC50 > 100000.0 nM -
CHEMBL3797638 IC50 > 100000.0 nM -
CHEMBL3797703 IC50 > 100000.0 nM -
CHEMBL3798000 IC50 > 100000.0 nM -
CHEMBL3799747 IC50 > 100000.0 nM -
CHEMBL3797384 IC50 > 100000.0 nM -
CHEMBL3799006 IC50 > 100000.0 nM -
CHEMBL3800179 IC50 > 100000.0 nM -
CHEMBL3798998 IC50 > 100000.0 nM -
CHEMBL3799080 IC50 > 100000.0 nM -
CHEMBL3799526 IC50 > 100000.0 nM -
CHEMBL3799361 IC50 > 100000.0 nM -
CHEMBL3797944 IC50 > 100000.0 nM -
CHEMBL3798483 IC50 > 100000.0 nM -
CHEMBL3799429 IC50 > 100000.0 nM -
CHEMBL3797374 IC50 > 100000.0 nM -
CHEMBL3798693 IC50 > 100000.0 nM -