Assay Detail
Binding
CHEMBL3803166
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Inhibition of CDK2 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.34 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3799935 | — | — | 1 | 5.89 |
| CHEMBL3798762 | — | — | 1 | 5.85 |
| CHEMBL3797873 | — | — | 1 | 5.47 |
| CHEMBL3797828 | — | — | 1 | 5.40 |
| CHEMBL3797574 | — | — | 1 | 5.24 |
| CHEMBL3798066 | — | — | 1 | 4.96 |
| CHEMBL3797559 | — | — | 1 | 4.60 |
| CHEMBL3800585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3799935 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3798762 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3797873 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3797828 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3797574 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3798066 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3797559 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3800585 | — | IC50 | > | 25000.0 | nM | - |