Assay Detail
Binding
CHEMBL3803215
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and preliminary biological evaluation of 4-aminopyrazole derivatives as novel and potent JAKs inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.12 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | 4.0 | 1 | 8.40 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 8.15 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105759 | BARICITINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 15.0 | nM | 7.82 |