Assay Detail
Binding
CHEMBL3806574
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Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition measured for 15 mins by spectrofluorimetric analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 4.63 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1673064 | — | — | 1 | 6.68 |
| CHEMBL3805288 | — | — | 1 | 5.15 |
| CHEMBL3805028 | — | — | 1 | 4.82 |
| CHEMBL3806197 | — | — | 1 | 4.71 |
| CHEMBL3805573 | — | — | 1 | 4.68 |
| CHEMBL3805495 | — | — | 1 | 4.68 |
| CHEMBL3806187 | — | — | 1 | 4.68 |
| CHEMBL3805118 | — | — | 1 | 4.62 |
| CHEMBL3805817 | — | — | 1 | 4.58 |
| CHEMBL3804956 | — | — | 1 | 4.58 |
| CHEMBL3804856 | — | — | 1 | 4.55 |
| CHEMBL3806230 | — | — | 1 | 4.25 |
| CHEMBL3805472 | — | — | 1 | 4.19 |
| CHEMBL3805338 | — | — | 1 | 4.17 |
| CHEMBL3805487 | — | — | 1 | 4.16 |
| CHEMBL3805193 | — | — | 1 | 4.15 |
| CHEMBL3805964 | — | — | 1 | 4.14 |
| CHEMBL3806247 | — | — | 1 | - |
| CHEMBL3805544 | — | — | 1 | - |
| CHEMBL3805251 | — | — | 1 | - |
| CHEMBL3806100 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1673064 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3805288 | — | Ki | = | 7020.0 | nM | 5.15 |
| CHEMBL3805028 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL3806197 | — | Ki | = | 19500.0 | nM | 4.71 |
| CHEMBL3805573 | — | Ki | = | 20800.0 | nM | 4.68 |
| CHEMBL3805495 | — | Ki | = | 21100.0 | nM | 4.68 |
| CHEMBL3806187 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL3805118 | — | Ki | = | 23800.0 | nM | 4.62 |
| CHEMBL3805817 | — | Ki | = | 26200.0 | nM | 4.58 |
| CHEMBL3804956 | — | Ki | = | 26500.0 | nM | 4.58 |
| CHEMBL3804856 | — | Ki | = | 28300.0 | nM | 4.55 |
| CHEMBL3806230 | — | Ki | = | 55800.0 | nM | 4.25 |
| CHEMBL3805472 | — | Ki | = | 64400.0 | nM | 4.19 |
| CHEMBL3805338 | — | Ki | = | 68400.0 | nM | 4.17 |
| CHEMBL3805487 | — | Ki | = | 69100.0 | nM | 4.16 |
| CHEMBL3805193 | — | Ki | = | 71100.0 | nM | 4.15 |
| CHEMBL3805964 | — | Ki | = | 72600.0 | nM | 4.14 |
| CHEMBL3806247 | — | Ki | = | 119000.0 | nM | - |
| CHEMBL3805544 | — | Ki | = | 108000.0 | nM | - |
| CHEMBL3805251 | — | Ki | = | 240000.0 | nM | - |
| CHEMBL3806100 | — | Ki | = | 289000.0 | nM | - |