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Assay Detail

CHEMBL3807014

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of His-tagged human recombinant caspase 7 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Caspase-7 (CHEMBL3468)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Protective effect of novel substituted nicotine hydrazide analogues against hypoxic brain injury in neonatal rats via inhibition of caspase.
Deng CB, Li J, Li LY, Sun FJ.
Bioorg Med Chem Lett (2016) 26 : 3195 -3201
PubMed 27216999 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 7.22 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL417149 1 7.22
CHEMBL3805818 1 -
CHEMBL3805231 1 -
CHEMBL3804942 1 -
CHEMBL3805109 1 -
CHEMBL3805088 1 -
CHEMBL3805942 1 -
CHEMBL3805488 1 -
CHEMBL3805483 1 -
CHEMBL3805916 1 -
CHEMBL3805458 1 -
CHEMBL3805744 1 -
CHEMBL3806289 1 -
CHEMBL3806253 1 -
CHEMBL3805593 1 -
CHEMBL3805833 1 -
CHEMBL3805972 1 -
CHEMBL3805517 1 -
CHEMBL3805045 1 -
CHEMBL3805555 1 -
CHEMBL3805679 1 -
CHEMBL3806315 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL417149 IC50 = 60.4 nM 7.22
CHEMBL3805818 IC50 - -
CHEMBL3805231 IC50 - -
CHEMBL3804942 IC50 - -
CHEMBL3805109 IC50 > 200000.0 nM -
CHEMBL3805088 IC50 - -
CHEMBL3805942 IC50 > 200000.0 nM -
CHEMBL3805488 IC50 - -
CHEMBL3805483 IC50 - -
CHEMBL3805916 IC50 - -
CHEMBL3805458 IC50 - -
CHEMBL3805744 IC50 > 200000.0 nM -
CHEMBL3806289 IC50 - -
CHEMBL3806253 IC50 - -
CHEMBL3805593 IC50 - -
CHEMBL3805833 IC50 - -
CHEMBL3805972 IC50 > 200000.0 nM -
CHEMBL3805517 IC50 > 200000.0 nM -
CHEMBL3805045 IC50 > 200000.0 nM -
CHEMBL3805555 IC50 > 200000.0 nM -
CHEMBL3805679 IC50 - -
CHEMBL3806315 IC50 - -