Assay Detail
Binding
CHEMBL3807136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.56 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146227 | — | — | 1 | 7.37 |
| CHEMBL445990 | — | — | 1 | 6.96 |
| CHEMBL3804851 | — | — | 1 | 6.68 |
| CHEMBL3804953 | — | — | 1 | 6.64 |
| CHEMBL3805642 | — | — | 1 | 6.47 |
| CHEMBL92084 | — | — | 1 | 5.95 |
| CHEMBL3805223 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146227 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL445990 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3804851 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3804953 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3805642 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL92084 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL3805223 | — | IC50 | = | 1380.0 | nM | 5.86 |