Assay Detail
Binding
CHEMBL3807232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant His-tagged PARP1 autoparsylation expressed in sf21 cells using NAD and biotinylated NAD incubated for 150 mins by HTRF assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potential Use of Inhibitors of Tankyrases and PARP-1 as Treatment for Cancer and Other Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.09 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3805627 | — | — | 1 | 6.92 |
| CHEMBL3805896 | — | — | 1 | 6.14 |
| CHEMBL3805393 | — | — | 1 | 5.92 |
| CHEMBL3806049 | — | — | 1 | 5.75 |
| CHEMBL3804939 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3805627 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3805896 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3805393 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3806049 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3804939 | — | IC50 | = | 1900.0 | nM | 5.72 |