Assay Detail
Binding
CHEMBL3807263
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Inhibition of recombinant Influenza A/X-31 virus PA infected in HEK293T cells after 2 hrs by vRNP reconstitution assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/X-31(H3N2)) |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polymerase acidic protein (CHEMBL3621021) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/X-31 H3N2) |
Publication
Novel indoleflutimide heterocycles with activity against influenza PA endonuclease and hepatitis C virus
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.22 | 4.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3805012 | — | — | 1 | 4.32 |
| CHEMBL3805551 | — | — | 1 | 4.12 |
| CHEMBL19332 | — | — | 1 | - |
| CHEMBL3804998 | — | — | 1 | - |
| CHEMBL3806243 | — | — | 1 | - |
| CHEMBL3805876 | — | — | 1 | - |
| CHEMBL3805084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3805012 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3805551 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL19332 | — | EC50 | - | — | - | |
| CHEMBL3804998 | — | EC50 | - | — | - | |
| CHEMBL3806243 | — | EC50 | = | 114000.0 | nM | - |
| CHEMBL3805876 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL3805084 | — | EC50 | = | 297000.0 | nM | - |