Assay Detail
Binding
CHEMBL3810522
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Inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate incubated for 10 mins by UV-Visible spectrophotometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel hydroxypyridinone derivatives as potential tyrosinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.04 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3810334 | — | — | 1 | 5.71 |
| CHEMBL3809975 | — | — | 1 | 5.55 |
| CHEMBL3810170 | — | — | 1 | 5.16 |
| CHEMBL3808924 | — | — | 1 | 4.93 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.90 |
| CHEMBL3808959 | — | — | 1 | 4.90 |
| CHEMBL3809951 | — | — | 1 | 4.85 |
| CHEMBL3808964 | — | — | 1 | 4.81 |
| CHEMBL3809467 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3810334 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL3809975 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL3810170 | — | IC50 | = | 6930.0 | nM | 5.16 |
| CHEMBL3808924 | — | IC50 | = | 11760.0 | nM | 4.93 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3808959 | — | IC50 | = | 12480.0 | nM | 4.90 |
| CHEMBL3809951 | — | IC50 | = | 14260.0 | nM | 4.85 |
| CHEMBL3808964 | — | IC50 | = | 15620.0 | nM | 4.81 |
| CHEMBL3809467 | — | IC50 | = | 28710.0 | nM | 4.54 |