Assay Detail
Binding
CHEMBL3811214
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Binding affinity to BACE1 (unknown origin) by surface plasmon resonance spectroscopic analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.29 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3809870 | — | — | 1 | 9.40 |
| CHEMBL3809662 | — | — | 1 | 9.22 |
| CHEMBL3808441 | — | — | 1 | 8.10 |
| CHEMBL3809897 | — | — | 1 | 7.96 |
| CHEMBL3808988 | — | — | 1 | 7.80 |
| CHEMBL3808967 | — | — | 1 | 7.60 |
| CHEMBL3808672 | — | — | 1 | 6.85 |
| CHEMBL1821803 | — | — | 1 | 4.70 |
| CHEMBL1454208 | — | — | 1 | 3.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3809870 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL3809662 | — | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL3808441 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL3809897 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL3808988 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL3808967 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL3808672 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL1821803 | — | Kd | = | 20000.0 | nM | 4.70 |
| CHEMBL1454208 | — | Kd | = | 114000.0 | nM | 3.94 |