Assay Detail
Binding
CHEMBL3811631
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Inhibition of human recombinant COX2 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by enzyme immunoassay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.79 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.70 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.40 |
| CHEMBL3809863 | — | — | 1 | 7.30 |
| CHEMBL3809156 | — | — | 1 | 7.22 |
| CHEMBL3809842 | — | — | 1 | 7.10 |
| CHEMBL3808627 | — | — | 1 | 7.00 |
| CHEMBL3809958 | — | — | 1 | 6.70 |
| CHEMBL3809120 | — | — | 1 | 6.52 |
| CHEMBL3809116 | — | — | 1 | 6.40 |
| CHEMBL3810167 | — | — | 1 | 6.30 |
| CHEMBL3809154 | — | — | 1 | 6.00 |
| CHEMBL3810057 | — | — | 1 | 5.70 |
| CHEMBL3809328 | — | — | 1 | 5.70 |
| CHEMBL3809760 | — | — | 1 | 5.52 |
| CHEMBL3810258 | — | — | 1 | 5.10 |
| CHEMBL3808663 | — | — | 1 | 5.10 |
| CHEMBL3809922 | — | — | 1 | 5.00 |
| CHEMBL3809099 | — | — | 1 | 4.72 |
| CHEMBL3810371 | — | — | 1 | 4.70 |
| CHEMBL3808516 | — | — | 1 | 4.66 |
| CHEMBL3809163 | — | — | 1 | 4.55 |
| CHEMBL3810231 | — | — | 1 | 4.26 |
| CHEMBL3808774 | — | — | 1 | 4.25 |
| CHEMBL3810027 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL118 | CELECOXIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3809863 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3809156 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3809842 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3808627 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3809958 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3809120 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3809116 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3810167 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3809154 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3810057 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3809328 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3809760 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3810258 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3808663 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3809922 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3809099 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3810371 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3808516 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3809163 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3810231 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL3808774 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL3810027 | — | IC50 | = | 75000.0 | nM | 4.12 |