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Assay Detail

CHEMBL3811652

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Binding
Competitive binding affinity to BRD9 bromodomain (unknown origin) measured after 1 hr by BROMOscan assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bromodomain-containing protein 9 (CHEMBL3108640)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
Unzue A, Zhao H, Lolli G, Dong J, Zhu J, Zechner M, Dolbois A, Caflisch A, Nevado C.
J Med Chem (2016) 59 : 3087 -3097
PubMed 26982797 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 18 5.31 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3809575 1 5.46
CHEMBL3810303 1 5.28
CHEMBL3809876 1 5.20
CHEMBL3808713 1 -
CHEMBL3809158 1 -
CHEMBL3809627 1 -
CHEMBL3810380 1 -
CHEMBL3808929 1 -
CHEMBL3809078 1 -
CHEMBL3808741 1 -
CHEMBL3810195 1 -
CHEMBL3809330 1 -
CHEMBL3808729 1 -
CHEMBL3809834 1 -
CHEMBL3809048 1 -
CHEMBL3808455 1 -
CHEMBL3809636 1 -
CHEMBL3809026 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3809575 Kd = 3500.0 nM 5.46
CHEMBL3810303 Kd = 5300.0 nM 5.28
CHEMBL3809876 Kd = 6300.0 nM 5.20
CHEMBL3808713 Kd - -
CHEMBL3809158 Kd - -
CHEMBL3809627 Kd - -
CHEMBL3810380 Kd - -
CHEMBL3808929 Kd - -
CHEMBL3809078 Kd - -
CHEMBL3808741 Kd - -
CHEMBL3810195 Kd - -
CHEMBL3809330 Kd - -
CHEMBL3808729 Kd - -
CHEMBL3809834 Kd - -
CHEMBL3809048 Kd - -
CHEMBL3808455 Kd - -
CHEMBL3809636 Kd > 50000.0 nM -
CHEMBL3809026 Kd - -