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Assay Detail

CHEMBL3812149

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiangiogenic activity in HUVEC after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HUVEC
Confidence 1 — Organism
Curated By Autocuration

Target

HUVEC (CHEMBL613979)
Type CELL-LINE
Organism Homo sapiens

Publication

Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors.
Daydé-Cazals B, Fauvel B, Singer M, Feneyrolles C, Bestgen B, Gassiot F, Spenlinhauer A, Warnault P, Van Hijfte N, Borjini N, Chevé G, Yasri A.
J Med Chem (2016) 59 : 3886 -3905
PubMed 27010810 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 6.61 7.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3808884 1 7.47
CHEMBL3809155 1 7.08
CHEMBL3808527 1 7.01
CHEMBL3808681 1 6.93
CHEMBL3808421 1 6.79
CHEMBL3809462 1 6.77
CHEMBL3810116 1 6.70
CHEMBL3809960 1 6.53
CHEMBL3809290 1 6.41
CHEMBL3809233 1 6.37
CHEMBL3810358 1 6.20
CHEMBL3810275 1 6.16
CHEMBL1336 SORAFENIB 4.0 1 6.14
CHEMBL3809705 1 6.01
CHEMBL3809041 1 -
CHEMBL3808739 1 -
CHEMBL3808466 1 -
CHEMBL3808753 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3808884 EC50 = 34.0 nM 7.47
CHEMBL3809155 EC50 = 83.0 nM 7.08
CHEMBL3808527 EC50 = 97.0 nM 7.01
CHEMBL3808681 EC50 = 118.0 nM 6.93
CHEMBL3808421 EC50 = 163.0 nM 6.79
CHEMBL3809462 EC50 = 171.0 nM 6.77
CHEMBL3810116 EC50 = 199.0 nM 6.70
CHEMBL3809960 EC50 = 298.0 nM 6.53
CHEMBL3809290 EC50 = 390.0 nM 6.41
CHEMBL3809233 EC50 = 426.0 nM 6.37
CHEMBL3810358 EC50 = 631.0 nM 6.20
CHEMBL3810275 EC50 = 689.0 nM 6.16
CHEMBL1336 SORAFENIB EC50 = 718.0 nM 6.14
CHEMBL3809705 EC50 = 986.0 nM 6.01
CHEMBL3809041 EC50 > 1000.0 nM -
CHEMBL3808739 EC50 > 1000.0 nM -
CHEMBL3808466 EC50 > 1000.0 nM -
CHEMBL3808753 EC50 > 1000.0 nM -