Assay Detail
Functional
CHEMBL3812151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.68 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3808884 | — | — | 1 | 7.19 |
| CHEMBL3808527 | — | — | 1 | 6.69 |
| CHEMBL3808421 | — | — | 1 | 6.53 |
| CHEMBL3809155 | — | — | 1 | 6.30 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3808884 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3808527 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL3808421 | — | EC50 | = | 293.0 | nM | 6.53 |
| CHEMBL3809155 | — | EC50 | = | 495.0 | nM | 6.30 |
| CHEMBL553 | ERLOTINIB | EC50 | > | 1000.0 | nM | - |
| CHEMBL1336 | SORAFENIB | EC50 | > | 1000.0 | nM | - |
| CHEMBL1946170 | REGORAFENIB | EC50 | > | 1000.0 | nM | - |