Assay Detail
Functional
CHEMBL3812152
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Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.85 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3808884 | — | — | 1 | 7.43 |
| CHEMBL3808527 | — | — | 1 | 6.82 |
| CHEMBL3809155 | — | — | 1 | 6.64 |
| CHEMBL3808421 | — | — | 1 | 6.52 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3808884 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3808527 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3809155 | — | EC50 | = | 227.0 | nM | 6.64 |
| CHEMBL3808421 | — | EC50 | = | 303.0 | nM | 6.52 |
| CHEMBL553 | ERLOTINIB | EC50 | > | 1000.0 | nM | - |
| CHEMBL1336 | SORAFENIB | EC50 | > | 1000.0 | nM | - |
| CHEMBL1946170 | REGORAFENIB | EC50 | > | 1000.0 | nM | - |