Assay Detail
Binding
CHEMBL3812822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine testis hyaluronidase using hyaluronic acid as substrate preincubated for 20 mins followed by incubation with CaCl2 for 20 mins and substrate for 10 mins by colorimetric Morgan-Elson method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Interpreting the behavior of concentration-response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.86 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | 2.0 | 1 | 5.07 |
| CHEMBL3809846 | — | — | 1 | 4.64 |
| CHEMBL485818 | BAICALIN | — | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL74 | CROMOLYN SODIUM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441687 | GLYCYRRHIZIN | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3809846 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL485818 | BAICALIN | IC50 | = | 450000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 340000.0 | nM | - |
| CHEMBL74 | CROMOLYN SODIUM | IC50 | = | 330000.0 | nM | - |