Assay Detail
Binding
CHEMBL3815409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of FLT3 ITD mutant (unknown origin) in presence of ATP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.03 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 8.70 |
| CHEMBL2105728 | CRENOLANIB | 3.0 | 1 | 8.52 |
| CHEMBL3815054 | — | — | 1 | 8.00 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2105728 | CRENOLANIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3815054 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 130.0 | nM | 6.89 |