Assay Detail
Binding
CHEMBL3815410
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3 D835Y mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.83 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3815054 | — | — | 1 | 8.40 |
| CHEMBL3814908 | — | — | 1 | 8.22 |
| CHEMBL3814657 | — | — | 1 | 7.58 |
| CHEMBL3814446 | — | — | 1 | 7.51 |
| CHEMBL3814462 | — | — | 1 | 7.47 |
| CHEMBL3814734 | — | — | 1 | 7.40 |
| CHEMBL3814055 | — | — | 1 | 7.21 |
| CHEMBL3814090 | — | — | 1 | 7.08 |
| CHEMBL3814207 | — | — | 1 | 7.02 |
| CHEMBL3814032 | — | — | 1 | 7.02 |
| CHEMBL3815134 | — | — | 1 | 6.94 |
| CHEMBL3814654 | — | — | 1 | 6.90 |
| CHEMBL3813745 | — | — | 1 | 6.44 |
| CHEMBL3814702 | — | — | 1 | 6.37 |
| CHEMBL3813913 | — | — | 1 | 6.30 |
| CHEMBL3814677 | — | — | 1 | 6.16 |
| CHEMBL3814749 | — | — | 1 | 6.02 |
| CHEMBL3813943 | — | — | 1 | 5.82 |
| CHEMBL3814564 | — | — | 1 | 5.50 |
| CHEMBL3815101 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3815054 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3814908 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3814657 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3814446 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3814462 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3814734 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3814055 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3814090 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3814207 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3814032 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3815134 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL3814654 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3813745 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL3814702 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3813913 | — | IC50 | = | 502.0 | nM | 6.30 |
| CHEMBL3814677 | — | IC50 | = | 692.0 | nM | 6.16 |
| CHEMBL3814749 | — | IC50 | = | 946.0 | nM | 6.02 |
| CHEMBL3813943 | — | IC50 | = | 1526.0 | nM | 5.82 |
| CHEMBL3814564 | — | IC50 | = | 3166.0 | nM | 5.50 |
| CHEMBL3815101 | — | IC50 | = | 5815.0 | nM | 5.24 |