Assay Detail
Binding
CHEMBL3815411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3 ITD mutant (unknown origin) transduced in mouse Ba/F3 cells assessed as reduction in cell viability after 3 days by cell titer glo assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.72 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3815054 | — | — | 1 | 8.00 |
| CHEMBL3814657 | — | — | 1 | 7.85 |
| CHEMBL3814908 | — | — | 1 | 7.75 |
| CHEMBL3814446 | — | — | 1 | 7.48 |
| CHEMBL3814462 | — | — | 1 | 7.26 |
| CHEMBL3814734 | — | — | 1 | 7.13 |
| CHEMBL3814090 | — | — | 1 | 7.01 |
| CHEMBL3815134 | — | — | 1 | 6.91 |
| CHEMBL3814207 | — | — | 1 | 6.89 |
| CHEMBL3814055 | — | — | 1 | 6.84 |
| CHEMBL3814032 | — | — | 1 | 6.84 |
| CHEMBL3814654 | — | — | 1 | 6.74 |
| CHEMBL3813745 | — | — | 1 | 6.55 |
| CHEMBL3813913 | — | — | 1 | 6.45 |
| CHEMBL3814702 | — | — | 1 | 6.37 |
| CHEMBL3814677 | — | — | 1 | 6.03 |
| CHEMBL3815101 | — | — | 1 | 5.80 |
| CHEMBL3814749 | — | — | 1 | 5.65 |
| CHEMBL3813943 | — | — | 1 | 5.61 |
| CHEMBL3814564 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3815054 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3814657 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3814908 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3814446 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3814462 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3814734 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3814090 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3815134 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL3814207 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL3814055 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL3814032 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL3814654 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL3813745 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3813913 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL3814702 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL3814677 | — | IC50 | = | 937.0 | nM | 6.03 |
| CHEMBL3815101 | — | IC50 | = | 1577.0 | nM | 5.80 |
| CHEMBL3814749 | — | IC50 | = | 2244.0 | nM | 5.65 |
| CHEMBL3813943 | — | IC50 | = | 2485.0 | nM | 5.61 |
| CHEMBL3814564 | — | IC50 | = | 5707.0 | nM | 5.24 |