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Assay Detail

CHEMBL3815691

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against chloroquine-sensitive ring-stage Plasmodium falciparum 3D7 assessed as parasite viability after 72 hrs by malstat assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Bistacrine derivatives as new potent antimalarials.
Schmidt I, Pradel G, Sologub L, Golzmann A, Ngwa CJ, Kucharski A, Schirmeister T, Holzgrabe U.
Bioorg Med Chem (2016) 24 : 3636 -3642
PubMed 27316542 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 6.76 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3814557 1 7.70
CHEMBL73160 1 7.70
CHEMBL76 CHLOROQUINE 4.0 1 7.70
CHEMBL3813736 1 7.52
CHEMBL3813885 1 7.52
CHEMBL3814319 1 7.52
CHEMBL3814823 1 7.40
CHEMBL3814983 1 7.30
CHEMBL424707 1 7.30
CHEMBL32823 1 7.16
CHEMBL73800 1 7.00
CHEMBL3815015 1 6.96
CHEMBL386423 1 6.96
CHEMBL75274 1 6.96
CHEMBL211313 1 6.77
CHEMBL3814548 1 6.70
CHEMBL3813881 1 6.68
CHEMBL213377 1 6.40
CHEMBL378006 1 6.31
CHEMBL179732 1 6.20
CHEMBL3815079 1 5.82
CHEMBL62085 1 5.69
CHEMBL59977 1 5.49
CHEMBL62084 1 5.40
CHEMBL95 TACRINE 4.0 1 4.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3814557 IC50 = 20.0 nM 7.70
CHEMBL73160 IC50 = 20.0 nM 7.70
CHEMBL76 CHLOROQUINE IC50 = 20.0 nM 7.70
CHEMBL3813736 IC50 = 30.0 nM 7.52
CHEMBL3813885 IC50 = 30.0 nM 7.52
CHEMBL3814319 IC50 = 30.0 nM 7.52
CHEMBL3814823 IC50 = 40.0 nM 7.40
CHEMBL3814983 IC50 = 50.0 nM 7.30
CHEMBL424707 IC50 = 50.0 nM 7.30
CHEMBL32823 IC50 = 70.0 nM 7.16
CHEMBL73800 IC50 = 100.0 nM 7.00
CHEMBL3815015 IC50 = 110.0 nM 6.96
CHEMBL386423 IC50 = 110.0 nM 6.96
CHEMBL75274 IC50 = 110.0 nM 6.96
CHEMBL211313 IC50 = 170.0 nM 6.77
CHEMBL3814548 IC50 = 200.0 nM 6.70
CHEMBL3813881 IC50 = 210.0 nM 6.68
CHEMBL213377 IC50 = 400.0 nM 6.40
CHEMBL378006 IC50 = 490.0 nM 6.31
CHEMBL179732 IC50 = 630.0 nM 6.20
CHEMBL3815079 IC50 = 1520.0 nM 5.82
CHEMBL62085 IC50 = 2040.0 nM 5.69
CHEMBL59977 IC50 = 3230.0 nM 5.49
CHEMBL62084 IC50 = 4020.0 nM 5.40
CHEMBL95 TACRINE IC50 = 12500.0 nM 4.90