Assay Detail
Functional
CHEMBL3815693
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite viability after 72 hrs by malstat assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bistacrine derivatives as new potent antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.32 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386423 | — | — | 1 | 6.85 |
| CHEMBL424707 | — | — | 1 | 6.82 |
| CHEMBL3815015 | — | — | 1 | 6.80 |
| CHEMBL3814548 | — | — | 1 | 6.80 |
| CHEMBL32823 | — | — | 1 | 6.66 |
| CHEMBL75274 | — | — | 1 | 6.52 |
| CHEMBL179732 | — | — | 1 | 6.26 |
| CHEMBL211313 | — | — | 1 | 5.86 |
| CHEMBL378006 | — | — | 1 | 5.40 |
| CHEMBL213377 | — | — | 1 | 5.21 |
| CHEMBL73800 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386423 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL424707 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3815015 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3814548 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL32823 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL75274 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL179732 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL211313 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL378006 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL213377 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL73800 | — | IC50 | - | — | - |