Assay Detail
Binding
CHEMBL3815698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversible inhibition of recombinant Plasmodium falciparum falcipain 2 assessed as hydrolysis of Cbz-Phe-Arg-AMC measured after 10 mins by spectrofluorometric method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bistacrine derivatives as new potent antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.92 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814557 | — | — | 1 | 5.28 |
| CHEMBL424707 | — | — | 1 | 4.94 |
| CHEMBL3815015 | — | — | 1 | 4.83 |
| CHEMBL75274 | — | — | 1 | 4.77 |
| CHEMBL73160 | — | — | 1 | 4.76 |
| CHEMBL3814548 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814557 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL424707 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL3815015 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL75274 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL73160 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL3814548 | — | IC50 | - | — | - |