Assay Detail
Binding
CHEMBL3815701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.17 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2382401 | — | — | 1 | 8.30 |
| CHEMBL2382402 | — | — | 1 | 8.29 |
| CHEMBL2382403 | — | — | 1 | 8.21 |
| CHEMBL2382405 | — | — | 1 | 8.19 |
| CHEMBL2382337 | — | — | 1 | 8.12 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2382401 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2382402 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL2382403 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL2382405 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL2382337 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |