Assay Detail
Functional
CHEMBL3815852
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Antiproliferative activity against human K562 cells assessed as inhibition of cell survival after 48 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.78 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.00 |
| CHEMBL289480 | RILMENIDINE | 4.0 | 1 | 4.19 |
| CHEMBL3593723 | — | — | 1 | 4.16 |
| CHEMBL3814535 | — | — | 1 | - |
| CHEMBL3814593 | — | — | 1 | - |
| CHEMBL3814220 | — | — | 1 | - |
| CHEMBL3814521 | — | — | 1 | - |
| CHEMBL3814626 | — | — | 1 | - |
| CHEMBL3814276 | — | — | 1 | - |
| CHEMBL3814259 | — | — | 1 | - |
| CHEMBL3813724 | — | — | 1 | - |
| CHEMBL3815157 | — | — | 1 | - |
| CHEMBL3593725 | — | — | 1 | - |
| CHEMBL57895 | EFAROXAN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL289480 | RILMENIDINE | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3593723 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL3814535 | — | IC50 | = | 222000.0 | nM | - |
| CHEMBL3814593 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL3814220 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3814521 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3814626 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL3814276 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3814259 | — | IC50 | = | 224000.0 | nM | - |
| CHEMBL3813724 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL3815157 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL3593725 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL57895 | EFAROXAN | IC50 | > | 300000.0 | nM | - |