Assay Detail
Functional
CHEMBL3816129
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Antiviral activity against human rhinovirus 14 assessed as reduction in viral infection in human HeLa H1 cells pretreated for 1 to 2 hrs with virus followed by cell addition measured after 48 hrs by Celltiter-Glo reagent based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | rhinovirus B14 |
| Cell Type | HeLa H1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and structure-activity relationships of novel inhibitors of human rhinovirus 3C protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.96 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3813932 | — | — | 1 | 7.96 |
| CHEMBL3813976 | — | — | 1 | 7.89 |
| CHEMBL3814175 | — | — | 1 | 7.04 |
| CHEMBL3814566 | — | — | 1 | 6.33 |
| CHEMBL3815126 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3813932 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3813976 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3814175 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3814566 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3815126 | — | EC50 | = | 2500.0 | nM | 5.60 |